Canine hyperadrenocorticism (HAC), or Cushing’s disease, is one of the most commonly diagnosed endocrinopathies in the dog.
Pituitary-dependent HAC is usually a disease of the middle-aged to older dog, whereas adrenal-dependent HAC is seen most commonly in older dogs. Irrespective of the cause of Cushing’s, the result is always the same – more cortisol is produced than is actually needed, resulting in the slow development of a combination of clinical signs that are associated with the condition.
The combination of signalment, clinical signs and routine laboratory findings will often lead to a presumptive diagnosis of Cushing’s disease. However, confirmation of the diagnosis requires a positive result to one or more endocrine diagnostic tests.
For help and support with diagnosing Cushing’s log-in here
A range of support materials are available including a series of short webcasts with Dr Audrey Cook DACVIM DECVIM DABVP discussing the challenges of, and providing solutions to, communicating effectively with pet owners about Cushing's.
Treatment of Cushing’s disease may be achieved by surgery (adrenalectomy or trans-sphenoidal hypophysectomy), pituitary irradiation, or medical treatment. But since surgery and radiotherapy are complicated specialist procedures, medical treatment is often the easiest choice.
Vetoryl, containing trilostane, is the only veterinary licensed treatment for pituitary- and adrenal-dependent HAC. More info
Pre-Vetoryl Cortisol (PVC) is an improved monitoring method for dogs being treated for Cushing’s disease. The method has been introduced following recent studies that showed a lack of correlation between ACTH stimulation test results and the clinical status of dogs treated with Vetoryl.2,3
Log-in to learn more. Professor Ian Ramsey BVSc Phd DSAM FHEA FRCVS DipECVIM-CA of the Small Animal Hospital at the University of Glasgow presents a series of videos introducing PVC, discussing the supporting evidence and why you should consider PVC, and describing how to perform and interpret the test . Download the PVC treatment and monitoring flowchart or the Quality of Life Questionnaire.
If you are an owner and your dog has been diagnosed with Cushing’s disease please view our owner website.
1 Internal Report VET0818
2. WEHNER A. GLOECKNER S., SAUTER C., KRUSE D., STOCKHAUS C. & HARTMANN, K. (2013) Association between ACTH stimulation tests, clinical signs, and laboratory parameters in dogs with hyperadrenocorticism treated with Vetoryl. (Abstract) European College of Veterinary Internal Medicine Congress, Liverpool
3. MACFARLANE l., PARKIN T., RAMSEY I. (2016) Pre-trilostane and three-hour post trilostane cortisol to monitor trilostane therapy in dogs Veterinary Record 179 (23): 597