Ashlee Watts. PhD, DVM, DACVS. Assistant Professor, Equine Orthopedics. Texas A&M University.
(Mitchell et al. 2019)
Chris Kawcak, PhD, DVM, DACVS, DACVSMR. Professor, Orthopedics & Equine Sports Medicine. Colorado State University.
Bisphosphonate classes and how this affects use
Differences in lameness improvement at Day 56 after treatment
Side effects recorded during the clinical field trial were mild and transient (Frevel et al. 2017)
For more information about incidence and type of adverse reactions please click here.
Interactions with other medicinal products
Medications such as aminoglycosides, whose toxicity can be exacerbated by a reduction in serum calcium, and medications such as tetracyclines, that can reduce serum calcium, should not be given for 72 hours after administration of clodronic acid.
Concurrent administration of potentially nephrotoxic drugs, such as NSAIDs, should be approached with caution and renal function should be monitored.
For more information about warnings and interactions please click here.
- Markell R., Saviola G., Barker E. A., Conway J. D., Dujardin C. (2019). What do we know about clodronate now? A medical and veterinary perspective. Journal of Equine Veterinary Science https://doi.org/10.1016/j.jevs.2019.102874 102874.
- Frevel M., King B. L., Kolb D. S., Boswell R. P., Shoemaker R. S., Janicek J. C., Cole R.C., Poole H.M., Longhofer S. L. (2017). Clodronate disodium for treatment of clinical signs of navicular disease–a double-blinded placebo-controlled clinical trial. Pferdeheilkunde, 33, 271-279.
- Stoiber J., Koene M., Mageed M., Swagemakers J. H. (2017). Therapeutic options for treatment of navicular bone disease with clodronic acid under practice conditions-a retrospective case series with 35 horses. Tierärztliche Umschau 72(9), 324-330.
- Argüelles D., Saitua A., de Medina A. S., Muñoz J. A., Muñoz A. (2019). Clinical efficacy of clodronic acid in horses diagnosed with navicular syndrome: A field study using objective and subjective lameness evaluation. Research in Veterinary Science, 125, 298-304.
- Mitchell A., Wright G., Sampson S. N., Martin M., Cummings K., Gaddy D., Watts A. E. (2019). Clodronate improves lameness in horses without changing bone turnover markers. Equine Veterinary Journal, 51(3), 356-363.